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	<title>MY DOCTOR TELLS &#187; &#8216;an unquiet mind&#8217;</title>
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		<title>bipolar-disorder-manic-depressive-illness</title>
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		<pubDate>Thu, 23 Apr 2009 10:09:26 +0000</pubDate>
		<dc:creator>Dr. Ashok Koparday, Sexologist and Marriage Counselor, Accredited Sex Therapist, Medical Director: Sex Therapy, Education, Research Center, Samadhan, Mumbai, India</dc:creator>
				<category><![CDATA[DEPRESSION]]></category>
		<category><![CDATA['an unquiet mind']]></category>
		<category><![CDATA[anxiety with depression]]></category>
		<category><![CDATA[biplolar depression]]></category>
		<category><![CDATA[bipolar]]></category>
		<category><![CDATA[bipolar disorder]]></category>
		<category><![CDATA[delusions in mania]]></category>
		<category><![CDATA[depression]]></category>
		<category><![CDATA[DISEASES AFFECTING SEXUAL FUNCTIONS]]></category>
		<category><![CDATA[hallucinations in mania]]></category>
		<category><![CDATA[hypomania]]></category>
		<category><![CDATA[john hopkins university]]></category>
		<category><![CDATA[kay redfield jamison]]></category>
		<category><![CDATA[mania]]></category>
		<category><![CDATA[manic depressive illness]]></category>
		<category><![CDATA[manic depressive psychosis]]></category>
		<category><![CDATA[MDP]]></category>
		<category><![CDATA[prof psychiatry has Biporla disorder]]></category>
		<category><![CDATA[touched with fire]]></category>

		<guid isPermaLink="false">http://mydoctortells.com/?p=1323</guid>
		<description><![CDATA[Manic Depressive Illness is well known from historical time even before Hippocrates. I strongly recommend people with Manic Depressive Illness and their family (care providers) to read the book AN UNQUIET MIND. Dr. Kay Redfield Jamison, Professor of Psychiatry at the John Hopkins University has written about her own 'Manic Depressive Illness' in this book.]]></description>
			<content:encoded><![CDATA[<p><span id="more-1323"></span><br />
<a name="t">GO TO </a><a href="#b"> BOTTOM</a><br />
To Directly Go To The Topic Click Below </p>
<ol>
<li><a href="#h">Hypomania</a></li>
<li>
<a href="#m">Mania</a></li>
<li>
<a href="#d">Depression</a></li>
</ol>
<p><strong>Incidence:</strong><br />
Bipolar disorder has been estimated to affect more than 5 million Americans—<strong>about 3 out of every 100</strong> adults. It affects all cultures and ethnic groups equally.<br />
<a href="#b">GO TO BOTTOM</a></p>
<blockquote><p><strong>Kay Redfield Jamison </strong>is a clinical psychologist and Professor of Psychiatry at the Johns Hopkins University School of Medicine, who profiled <strong>her own bipolar disorder</strong> in her 1995 memoir<br />
<strong><em>An Unquiet Mind</em></strong>,<a href="#11"><sup>[11]</sup> </a>and argued for a connection between bipolar disorder and artistic creativity in her 1993 book, <strong><em>Touched with Fire</em>.</strong><a href="#12"><sup>[12]</sup></a></p></blockquote>
<h2>Bipolar Disorder</h2>
<p>Also called: <strong>Manic-depressive illness</strong><br />
Bipolar disorder is a condition in which people experience abnormally elevated (manic or hypomanic) and abnormally depressed states for a period of time in a way that interferes with functioning.<a href="#b">GO TO BOTTOM</a></p>
<h2><a name="h">HYPOMANIA</a></h2>
<p>People with Bipolar Disorder have times when they feel on top of the world. The person is bubbling with zest [Abnormally elevated mood] . This is the high phase of mood, called <strong>hypomania. </strong></p>
<blockquote><p>Such a person with hypomania has increased sex drive and may engage in inappropriate, promiscuous sex because of loss of inhibition and heightened self confidence.</p></blockquote>
<p>In hypomania person is gregarious, indiscriminately talks lot jumping over different topics, spends a lot of money irrationally.  Such a person sleeps less, has novel ideas, plans for grandiose activities.<br />
The severe form of hypomania is mania. All people with Bipolar Disorder do not have Mania.<br />
They may have one to three episodes of hypomania and the rest of the time they are in Depression. There may be  chunks of days when they are normal.<br />
<a href="#t">GO TO TOP </a><a href="#b">GO TO BOTTOM</a></p>
<h2><a name="m">MANIA</a></h2>
<p>When the person shows severe agitation, anger, irrelevant talk, false beliefs contrary to facts [DELUSIONS], actually sees someone who does not exist (HALLUCINATION) the person is in <strong>Mania.</strong> This person can be unmanageable and if not promptly diagnosed and treated requires physical restraint or chemical restraint (person is doped).<br />
MIXED EPISODES is when features of both mania and depression are present at the same time.<br />
RAPID CYCLING is when depression and mania rapidly alternate.<br />
<a href="#t">GO TO TOP </a><a href="#b">GO TO BOTTOM</a></p>
<h2><a name="d">DEPRESSION</a></h2>
<p>When the same person becomes asocial, diffident, deplete of energy, (OPPOSITE OF HYPOMANIA) the person is in a phase called Depression, which has same features as Endogenous Depression.</p>
<p>In fact, a person may be diagnosed initially as having <strong>Endogenous Depression</strong> or <strong>Anxiety with Depression</strong> until features of Bipolar Disorder surface.<a href="#b">GO TO BOTTOM</a> </p>
<p><em>The Bipolar Spectrum Diagnostic Scale (BSDS) was developed by Ronald Pies, MD and was later refined and tested by S. Nassir Ghaemi, MD, MPH and colleagues. The BSDS arose from Pies&#8217;s experience as a psychopharmacology consultant, where he was frequently called on to manage cases of &#8220;treatment-resistant depression.&#8221; There are 19 question items and 2 sections on the English version of the BSDS. The scale was validated in its original version and demonstrated a high sensitivity.</em><br />
The disorder has been subdivided into<br />
<strong>bipolar I, </strong><br />
<strong>bipolar II, </strong><br />
<strong>cyclothymia</strong>, and<br />
<strong>other types</strong>, based on the nature and severity of mood episodes experienced; the range is often described as the bipolar spectrum.<a href="#b">GO TO BOTTOM</a></p>
<h4>Get Help Here: Organizations in USA</h4>
<ol>
<li>
National Alliance for the Mentally Ill </p>
<p>http://www.nami.org</p>
<p>Colonial Place Three 2107 Wilson Blvd., Suite 300<br />
Arlington, VA 22201-3042<br />
800-950-6264 </li>
<li>
<p>National Mental Health Association </p>
<p>http://www.nmha.org</p>
<p>800-969-NMHA (800-969-6642)</li>
<li>
Depression and Bipolar Support Alliance </p>
<p>http://www.dbsalliance.org/</p>
<p>730 N. Franklin St., Suite 501<br />
Chicago, IL 60610-7204<br />
800-826-3632 </li>
</ol>
<p><a href="#t">GO TO TOP </a><a href="#b">GO TO BOTTOM</a><br />
1<br />
Safety Study of Sodium Divalproate in Bipolar Disorder in Adolescents (ADOKOT)<br />
This study has been completed.<br />
First Received: December 29, 2005   Last Updated: September 24, 2008<br />
History of Changes<br />
Sponsored by:<br />
Sanofi-Aventis<br />
Information provided by:<br />
Sanofi-Aventis<br />
ClinicalTrials.gov Identifier:<br />
NCT00271258</p>
<p>http://clinicaltrials.gov/ct2/show/NCT00271258</p>
<p><a href="#t">GO TO TOP </a><a href="#b">GO TO BOTTOM</a><br />
2<br />
<a href="http://www.freepatentsonline.com/6667420.html">Na Divalproate patent</a><br />
Process for the preparation of sodium divalproate &#8211; Patent 6667420<br />
3<br />
<a href="http://familydoctor.org/online/famdocen/home/common/mentalhealth/depression/625.printerview.html">familydoctor.org</a><br />
4<a href="http://www.nlm.nih.gov/medlineplus/bipolardisorder.html"><br />
National Institute of Mental Health &#8212; Bipolar Disorder</a><br />
<a href="http://www.familydoctor.org/online/famdocen/home/about/webteam.html">Written by familydoctor.org editorial staff</a>.<br />
<a href="http://http://www.aafp.org/afp/20000915/1343.html">Management of Bipolar Disorder</a> by KS Griswold, M.D., M.P.H. and LF Pessar, M.D. (American Family Physician September 15, 2000, <a href="http://www.aafp.org/afp/20000915/1343.html">http://www.aafp.org/afp/20000915/1343.html</a>)<br />
Reviewed/Updated: 11/06<br />
Created: 09/00<a href="http://www.familydoctor.org/online/famdocen/home/about/copyright.html"> Copyright</a> © 2000-2009<br />
4<br />
<a href="http://en.wikipedia.org/wiki/Bipolar_disorder">http://en.wikipedia.org/wiki/Bipolar_disorder</a><br />
5<br />
Psychiatric Times. Clinically Useful Psychiatric Scales: <a href="http://www.psychiatrictimes.com/clinical-scales/bsds/">Bipolar Spectrum Diagnostic Scale, </a><br />
Accessed on March 9, 2009.<br />
6<br />
Ghaemi N. Sensitivity and specificity of a new bipolar spectrum diagnostic scale. J Affect Disord. 2005;84:273-277.</p>
<p><a href="#t">GO TO TOP </a><br />
 <a name="11">11.</a>Jamison, Kay Redfield (1995). <strong>An Unquiet Mind</strong>: A Memoir of Moods and Madness. New York: Knopf.. ISBN 0-330-34651-2.<br />
 <a name="12">12.</a><br />
 Jamison, Kay Redfield (1996). <strong>Touched With Fire</strong>: Manic-Depressive Illness and the Artistic Temperament. New York: The Free Press: Macmillian, Inc.. ISBN 0-684-83183-X.</p>
<div style="float:right; width:40%;">
The following excerpt is from<br />
<strong>Medline Plus:</strong><br />
Bipolar disorder is a serious mental illness. People who have it experience dramatic mood swings. They may go from overly energetic, &#8220;high&#8221; and/or irritable, to sad and hopeless, and then back again. They often have normal moods in between. The up feeling is called mania. The down feeling is depression.<br />
<a href="#b">GO TO BOTTOM</a><br />
Bipolar disorder can run in families. It usually starts in late adolescence or early adulthood. If you think you may have it, tell your health care provider. A medical checkup can rule out other illnesses that might cause your mood changes.</p>
<p>Untreated, bipolar disorder can result in damaged relationships, poor job or school performance, and even suicide. However, there are effective treatments: medicines and &#8220;talk therapy&#8221;. A combination usually works best.<br />
<a href="#t">GO TO TOP </a><br />
1. MedlinePlus Drug Information:  <a href="http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a681039.html"><strong>Lithium.</strong></a>http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a681039.html. Accessed on Nov 19, 2007.</p>
<p>2. MedlinePlus Drug Information:  <a href="http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682237.html"><strong>Carbamazepine</strong>.</a><br />
http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682237.html. Accessed on July 13, 2007.</p>
<p>3. MedlinePlus Drug Information: <a href="http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a695007.html"><strong>Lamotrigine</strong>. </a>http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a695007.html. Accessed on February 12, 2008.</p>
<p>4. MedlinePlus Drug Information: <a href="http://http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682412.html"><strong>Valproic Acid.</strong> </a>http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682412.html. Accessed on February 12, 2008.<br />
<a href="#t">GO TO TOP </a><a href="#b">GO TO BOTTOM</a><br />
5. MedlinePlus Drug Information: <a href="http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a697012.html"><strong>Topiramate.</strong> </a>http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a697012.html. Accessed on Febrary 22, 2008.</p>
<p>6. MedlinePlus Drug Information: <a href="http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a694007.html"><strong>Gabapentin.</strong><br />
 </a>http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a694007.html. Accessed on February 22, 2008.</p>
<p>7. MedlinePlus Drug Information: <a href="http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682412.html"><strong>Oxcarbazepine.</strong> </a>http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a601245.html.<br />
Accessed on February 22, 2008.<br />
<a href="http://www.nlm.nih.gov/medlineplus/bipolardisorder.html"><br />
National Institute of Mental Health</a></p>
<p>http://www.nlm.nih.gov/medlineplus/bipolardisorder.html</p>
<p>From<br />
<strong> The Mental Health Today</strong><br />
FAMILY HISTORY &#8211; GENETIC<br />
First-degree biological relatives of individuals with Bipolar I Disorder have elevated rates of Bipolar I Disorder (4%-24%), Bipolar II Disorder (1%-5%), and Major Depressive Disorder (4%-24%). Twin and adoption studies provide strong evidence of a genetic influence for Bipolar I Disorder.<br />
<a href="http://www.mental-health-today.com/bp/bi1.htm">Mental Health Today</a>
</div>
<div style="float:left; width:40%;">
The following excerpt is from<br />
<strong>FamilyDoctor.org:</strong><br />
<strong>What are some of the signs of bipolar disorder?</strong></p>
<p>Bipolar Disorder/Depression also known as<br />
Manic Depressive Illness/Psychosis MDP<br />
At times, a person who has bipolar disorder may feel very happy, full of energy and able to do anything. The person might not even want to rest when he or she feels this way. This feeling is called hypomania (say: &#8220;hypo may-nee-ah&#8221;). At other times, a person who has bipolar disorder may feel very sad and depressed. The person may not want to do anything when he or she feels this way. This is called depression. People with bipolar disorder can quickly go from mania to depression and back again.</p>
<p><a href="#t">GO TO TOP </a><a href="#b">GO TO BOTTOM</a><br />
Other signs of mania may include the following:</p>
<ol>
<li>Feeling very irritable or angry</li>
<li>
     Thinking and talking so fast that other people can&#8217;t follow your thoughts</li>
<li>
     Not sleeping at all</li>
<li>
    Feeling very powerful and important</li>
<li>
     Having trouble concentrating</li>
<li>
    Spending too much money</li>
<li>
   Abusing alcohol and drugs</li>
<li>
    Having sex without being careful to prevent pregnancy or disease</li>
</ol>
<p><a href="#t">GO TO TOP </a><a href="#b">GO TO BOTTOM</a><br />
Other signs of depression may include the following:</p>
<ol>
<li>
 No interest or pleasure in things you used to enjoy, including sex	</li>
<li>
<p>    Feeling sad or numb</li>
<li>
<p>    Crying easily or for no reason</li>
<li>  Feeling slowed down, or feeling restless and irritable</li>
<li>
<p>    Feeling worthless or guilty</li>
<li>
    Change in appetite; unintended change in weight</li>
<li>
   Trouble recalling things, concentrating or making decisions</li>
<li>
   Headaches, backaches or digestive problems </li>
<li>
    Problems sleeping, or wanting to sleep all of the time</li>
<li>
     Feeling tired all of the time</li>
<li>
    Thoughts about death and suicide</li>
</ol>
<p><a href="http://familydoctor.org/online/famdocen/home/common/mentalhealth/depression/625.printerview.html">FamilyDoctor.org</a><br />
http://familydoctor.org/online/famdocen/home/common/mentalhealth/depression/625<a name="b">.printerview.html</a>
</div>
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