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		<title>how-medicines-are-tested</title>
		<link>http://mydoctortells.com/how-medicines-are-tested/</link>
		<comments>http://mydoctortells.com/how-medicines-are-tested/#comments</comments>
		<pubDate>Thu, 08 Jan 2009 05:10:45 +0000</pubDate>
		<dc:creator>Dr. Ashok Koparday, Sexologist and Marriage Counselor, Accredited Sex Therapist, Medical Director: Sex Therapy, Education, Research Center, Samadhan, Mumbai, India</dc:creator>
				<category><![CDATA[MEDICINE]]></category>
		<category><![CDATA[American Heritage Dictionary of the English Language]]></category>
		<category><![CDATA[Biotechnology and Pharmaceuticals]]></category>
		<category><![CDATA[Business]]></category>
		<category><![CDATA[Clinicaltrial]]></category>
		<category><![CDATA[Medication]]></category>
		<category><![CDATA[Placebo]]></category>
		<category><![CDATA[Scientific method]]></category>

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		<description><![CDATA[How medicine is tested to prove effects and possible side effects? 
Use2 How Placebo is used in experimental Clinical trial?]]></description>
			<content:encoded><![CDATA[<p><span id="more-751"></span><br />
<a name="t"><strong>GENUINE MEDICINE</strong></a><br />
We have seen how PLACEBO helps in healing.<a href="medicines-with-no-sideeffects-placebo-cures/">click </a><a href="http://mydoctortells.com/medicines-with-no-sideeffects-placebo-cures/">here</a><br />
USE2 of placebo<br />
This topic shows scientific method adopted before calling a substance as &#8216;cure&#8217; or &#8216;medicine&#8217; or &#8216;healer&#8217;.</p>
<p>This is interesting because it shows the difference between Current or Modern Medical Systems and other Healing Systems or Medicines.</p>
<p><a href="#b"> TO BOTTOM</a><br />
HOW MEDICAL SCIENCE DECIDES WHETHER MEDICINE IS GENUINE AND BENEFICIAL? HOW MEDICAL SCIENTISTS STUDY EFFECTS AND SIDE EFFECTS ?<br />
HOW TO DIFFERENTIATE BETWEEN PROVEN TREATMENT AND UNPROVEN THOSE MEDICINES THAT ARE CLAIMED TO CURE WHERE YOUR HEALTH (AND WEALTH) ARE AT RISK?<br />
Here we will see what is <a href="#1">[i] </a>Placebo that is used for Clinical trial,  <a href="#2">[ii] </a>Random Double Blind Placebo Controlled Clinical Trial <a href="#3">[iii]</a> Active Placebo and <a href="#4">[iv]</a> Nacebo</p>
<p><strong><a name="1">[i]</a> Placebo &#8211; Experimental Research Purpose</strong></p>
<p>Placebo is used in Clinical Trial or Experiments to prove efficacy of a drug, often a &#8216;New Medicine&#8217;.<br />
When Scientists want to confirm the effects and side effects of &#8216;New Medicine&#8217; along with the  &#8216;New Medicine&#8217; Placebo is used.  This study is <strong>done usually BEFORE the medicine is introduced in the market. </strong>Food and Drugs Control Department has to ascertain that the  &#8216;New Medicine&#8217; does the work as the Manufacturer/Research Scientists claim.<br />
<a href="#t"> TO TOP</a><br />
<a href="#b"> TO BOTTOM</a><br />
HOW SCIENTISTS STUDY EFFECT OF &#8216;New Medicine&#8217;?</p>
<p>EXAMPLE</p>
<p>Research Scientists give Actual &#8216;New Medicine&#8217; to 100 patients of (let us call Group A) Group A. Other 100 patients (let us call Group B) receive &#8216;Look Alike of New Medicine&#8217; called as Placebo and not the actual medicine.<br />
<a href="#t"> TO TOP</a><br />
<a href="#b"> TO BOTTOM</a><br />
INTERPRETATION:</p>
<p>Those taking the &#8216;Look Alike of New Medicine&#8217;, Group B, will neither show harmful effects nor beneficial effects. This is compared with Group A patients who have used Actual &#8216;New Medicine&#8217;.  Those who have used the Actual &#8216;New Medicine&#8217; will show beneficial effects of the &#8216;New Medicine&#8217;, as well as the side effects.</p>
<p>Since, beneficial effect or side effect is not seen in those who have taken Placebo, that is , &#8216;Look Alike of New Medicine&#8217;, Medical Scientists prove that the &#8216;New Medicine&#8217; does produce effects as claimed by them. This study done by Research Scientists/Pharmaceutical Companies is scrutinized for veracity by regulatory body like Foods and Drugs Control and other Research Scientists working in the same way in other countries/universities.<br />
<a href="#t"> TO TOP</a><br />
<a href="#b"> TO BOTTOM</a><br />
<strong><a name="2">[ii]</a> Random Double Blind Placebo Controlled Clinical Trial</strong> is where neither those giving the medicines nor taking the medicine know which is the Actual &#8216;New Medicine&#8217; and Placebo. This eliminates the bias or pre-notion of both Givers and Receivers. Actual &#8216;New Medicine&#8217; and Placebo have technically distinguishing marks, which tells later who received Actual &#8216;New Medicine&#8217; and Placebo.<br />
<a href="#t"> TO TOP</a><br />
<a href="#b"> TO BOTTOM</a><br />
USE2 Here is the <strong>definition of Placebo</strong> that is used for clinical trial</p>
<blockquote><p>An inactive substance with no pharmacological action that is administered to some patients in clinical trials to determine the relative effectiveness of another drug administered to a second group of patients.</p></blockquote>
<p>Source: Mentioned in: <a href="http://medical-dictionary.thefreedictionary.com/Saw+Palmetto">Saw Palmetto</a>, <a href="http://medical-dictionary.thefreedictionary.com/Sildenafil+Citrate">Sildenafil Citrate</a><br />
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.</p>
<p><strong> </strong>USE2 Definition2 n</p>
<blockquote><p>inactive substance or preparation used as a control in an experiment or test to determine the effectiveness of a medicinal drug.</p></blockquote>
<p>Source: [2] The American Heritage® Dictionary of the English Language, Fourth Edition copyright ©2000 by Houghton Mifflin Company. Updated in 2003.<br />
<a href="#t"> TO TOP</a><br />
<a href="#b"> TO BOTTOM</a><br />
<strong><a name="3">[iii] </a>What is ACTIVE PLACEBO?</strong></p>
<p><strong>active placebo</strong> -</p>
<blockquote><p>Definition 1. a placebo used in experimental tests of a drug that has noticeable side effects; &#8220;an active placebo mimics the side effects of the experimental drug&#8221;</p></blockquote>
<p>Source: Based on WordNet 3.0, Farlex clipart collection. © 2003-2008 Princeton University, Farlex Inc.</p>
<blockquote>
<div class="ds-list">Definition 2. Placebos are also used in controlled clinical trials of new drugs. While some patients selected at random are given the new drug, others are given a placebo. Often this is an active placebo that mimics the new drug&#8217;s side-effects. Neither the patients nor the veterinarians know who is receiving the real drug. The patients taking the new drug must have significantly more relief of signs than the control group taking the placebo for the new drug to be considered to be effective. Placebos can produce an effect that is either positive, with improvement of signs, or negative, with worsening of signs or the appearance of adverse side-effects.</div>
</blockquote>
<div class="brand_copy">Source: Saunders Comprehensive Veterinary Dictionary, 3 ed. © 2007 Elsevier, Inc. All rights reserved</div>
<div class="brand_copy">
<p><strong><a name="4">[iv]</a> <span class="hw">nocebo</span></strong></p>
<blockquote><p><span class="hw">Definition: nocebo</span> Clinical trials A negative placebo effect that may occur when Pts in a clinical trial of a drug therapy recognize–or think they recognize that they are getting a placebo–ie, not receiving therapy, and fare worse due to the effect of negative suggestibility. Placebo</p></blockquote>
<p class="brand_copy">McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, <a name="b">Inc.</a></p>
</div>
<p><a href="#t"> TO TOP</a></p>
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		<title>medicines-with-no-sideeffects-placebo-cures</title>
		<link>http://mydoctortells.com/medicines-with-no-sideeffects-placebo-cures/</link>
		<comments>http://mydoctortells.com/medicines-with-no-sideeffects-placebo-cures/#comments</comments>
		<pubDate>Wed, 07 Jan 2009 16:59:20 +0000</pubDate>
		<dc:creator>Dr. Ashok Koparday, Sexologist and Marriage Counselor, Accredited Sex Therapist, Medical Director: Sex Therapy, Education, Research Center, Samadhan, Mumbai, India</dc:creator>
				<category><![CDATA[MEDICINE]]></category>
		<category><![CDATA[American Heritage Dictionary of the English Language]]></category>
		<category><![CDATA[Biotechnology and Pharmaceuticals]]></category>
		<category><![CDATA[Business]]></category>
		<category><![CDATA[Clinical trial]]></category>
		<category><![CDATA[Medication]]></category>
		<category><![CDATA[Placebo]]></category>
		<category><![CDATA[Scientific control]]></category>

		<guid isPermaLink="false">http://mydoctortells.com/?p=745</guid>
		<description><![CDATA[Use1 Placebo is type of harmless medicine that doctors often give to effectuate cure. The power of confidence and suggestion helps the healing system.   
Use2 The placebo used for clinical trial]]></description>
			<content:encoded><![CDATA[<p>Quote from The Secret<span id="more-745"></span></p>
<p><a href="#1">[1]</a></p>
<p><a name="t">&#8220;The </a>placebo effect is an example of law of attraction in action. When a patient truly believes the tablet is a cure, he receives what he believes and is cured.&#8221;<br />
The topic here is</p>
<h4>PLACEBO</h4>
<p>WHAT IS PLACEBO?<br />
WHY IS PLACEBO USED?</p>
<p><a href="#b">TO BOTTOM</a><br />
Placebo is used for TWO purposes.</p>
<p>USE1 healing (Therapeutics) and other is</p>
<p>USE2 research study (Clinical Trial) for a &#8216;New Medicine&#8217;. <a href="how-medicines-are-tested/">click here</a> for USE2</p>
<p>http://mydoctortells.com/how-medicines-are-tested/</p>
<p><a href="#t">TO TOP</a></p>
<p><a href="#b">TO BOTTOM</a></p>
<p>USE1 PLACEBO FOR HEALING<br />
Doctors in all faculties of medicine know the healing role of &#8216;placebo&#8217;. In Indian language, Marathi, vernacular, placebo is called as <em>&#8216;samadhankay&#8217;</em></p>
<p>Definition1. <strong>placebo therapeutics</strong>,</p>
<blockquote><p>n.pl treatments in which a physician attempts to engage the patient&#8217;s own healing processes by prescribing physiologically inactive stimuli.</p></blockquote>
<p>Definition 2. <strong>placebo effect</strong><br />
The patient&#8217;s innate healing, defense and survival processes that are elicited through the meaning and context of a treatment.<br />
Jonas: Mosby&#8217;s Dictionary of Complementary and Alternative Medicine. (c) 2005, Elsevier.</p>
<p><a href="#t">TO TOP</a></p>
<p><a href="#b">TO BOTTOM</a></p>
<p>USE2 Definition2</p>
<blockquote><p>n. inactive substance or preparation used as a control in an experiment or test to determine the effectiveness of a medicinal drug.</p></blockquote>
<p>Source: <a href="#2">[2] </a>The American Heritage® Dictionary of the English Language, Fourth Edition copyright ©2000 by Houghton Mifflin Company. Updated in 2003.</p>
<div class="brand_copy"><strong>REFERENCES</strong></div>
<p><a name="1">[1]</a><br />
The Secret by Rhonda Byrne<br />
quote page 139<br />
Titled Secret Summaries<br />
ATRIA BOOKS<br />
1230, Avenue of the Americas,<br />
New York<br />
NY 10020<br />
London</p>
<p>Beyond Woods Publishing<br />
www.beyondword.com</p>
<p><a name="2">[2]</a></p>
<p>word &#8216;placebo&#8217;</p>
<p>search dated January 07, 2009</p>
<p>website http://www.thefreedictionary.com/placebo</p>
<p>The American Heritage® Dictionary of the English Language, Fourth Edition copyright ©2000 by Houghton Mifflin Company. Updated in 2003. Published by <a href="http://www.eref-trade.hmco.com/" target="_blank">Houghton Mifflin Company</a>.<a name="b"> All</a> rights reserved.<br />
<a href="#t">TO TOP</a></p>
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